Nasal lesions induced by intranasal administration of benzalkonium chloride in rats.

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A mouse dry eye model induced by topical administration of benzalkonium chloride

PURPOSE To develop a dry eye model of mouse induced by topical administration of benzalkonium chloride (BAC) and investigate the possible mechanisms. METHODS BAC at concentration of 0.2% was applied to the mouse ocular surface for 7 days. Phenol red thread tear test, tear break-up time (BUT) test, corneal inflammatory index scoring, fluorescein and rose bengal test were performed to evaluate ...

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ژورنال

عنوان ژورنال: The Journal of Toxicological Sciences

سال: 1997

ISSN: 0388-1350,1880-3989

DOI: 10.2131/jts.22.2_153